Breed determination
We have more than 2000 dog genomes in our database and we continue to expand it. We also have genomes of 'village dogs' from around 18 nations around the world. These could enable a clearer understanding of the origins of a street dog. We have developed a sophisticated algorithm that analyzes the breed markers of each of your dog's chromosomes. In this way, we can determine the exact breed composition of your dog. Our test reports the breeds that are most represented in your dog, as well as their genetic proportion.
Hereditary diseases
In our PREMIUM test we check for the presence of mutations responsible for around 140 hereditary diseases.
Specifically, we report (among others):
- Eye diseases: Glaucoma, Lens Luxation, Multifocal Retinopathy, Epidermolysis Bullosa, Retinal Atrophy, Hyperkeratosis, Cataract, Progressive Rod-Cone Degeneration, Stargadt Disease and more.
- Skin diseases: Ichthyosis, Congenital Dermatosis, Exfoliative Lupus Erythematosus, Ehlers-Danlos Syndrome, Congenital Hypotrichosis, Lethal Acrodermatitis and more.
- Teeth/Bone diseases: Cleft Palate, Mucopolysaccharidosis, Amelogenesis Imperfecta, Dental Hypomineralization, Acatalasemia and more.
- Neurodegenerative diseases: Lipofuscinosis, Cerebellar Dysfunction, Gangliosidosis, Krabbe's Disease, Neuroaxonal Dystrophy, Sensory Neuropathy, Polyneuropathy and more.
- Kidney and liver diseases: Nephritic Syndrome, Polycystic Kidney Disease, Kidney Cancer, Hyperuricosuria, Cystinuria, Hyperoxaluria, PKD, Glycogen Storage Disease and more.
- Other diseases: EIC, Musladin-Lueke Syndrome (MLS), Acral Mutilation Syndrome, Malignant Hyperthermia, Muscular Dystrophy, Leukodystrophy, Bilateral Deafness, Albinism, Degenerative Myelopathy, Centronuclear Myopathy, Scott Syndrome, Congenital Myasthenic Syndrome, SCID, Von Willebrand Disease and more.
Genetic pedigree, Parental test
If you are interested in what your dog's parents looked like and what specific breed mix they were, or whether they were purebred, we calculate the breed ratio between your dog's two previous generations. If you have a purebred dog, we also calculate the inbreeding coefficient from our genome database. We offer paternity testing if you test both dogs that are suspected to be related.
Genetic source of traits
In the report you will find a decoding of the genetic variations that potentially lead to some of the characteristics you see and experience in your dog.
We test all the typical genetics for coat color and pattern: E-locus, A-locus (Agouti), B-locus (brown), Piebald/White spots, I/D-locus (dilution), K-locus (dominant black). In addition, we test L-locus (Length), curly coat, shape of the tail (bobtail). We continue to add new characteristics over time.
Note: for some dog breeds, coat color can be associated with some other genetic disorders.
Inbreeding coefficient
The inbreeding coefficient ranges along a continuum from 0% to 100%. Mixed breed dogs tend to have an inbreeding coefficient of around 5% on average (see references below for more details). This is not always the case; breeding related mixed breed dogs together can result in puppies with high IQs, just like purebreds. The average IQ for purebred dogs is ~20%. Specific breeds can be higher or lower than this value. For some breeds, the average inbreeding coefficient can approach or even exceed 40%.
Many of us are interested in knowing whether inbreeding will lead to health problems in our animals. Research suggests that there may be health consequences of inbreeding (see references below for more details). For example, higher levels of inbreeding are associated with shorter lifespans.
But again, this is an area of some nuance. Remember that a low inbreeding coefficient indicates higher heterozygosity, in other words, more genetic variation. Typically, this means that the individual has lower "genetic risk" and more "genetic options" when it comes to responding to environmental changes or disease exposure.
Our test
